Despair: Leads to Blasphemy
Source: TTT
Isaiah 8:21
They will roam the land, dejected and hungry. When they are famished, they will become enraged; and looking upward, they will curse their king and their God.
Revelation 16:10, 11
And the fifth angel poured out his bowl on the throne of the beast, and its kingdom was plunged into darkness, and men began to gnaw their tongues in anguish / and curse the God of heaven for their pains and sores; yet they did not repent of their deeds.